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Isotope Dilution Mass Spectrometry

2020-06-29T02:06:10+00:00
  • Isotope dilution - Wikipedia

    OverviewApplicationsEarly historyTutorial exampleSingle dilution methodDouble dilution methodTriple dilution methodCalculations using calibration curve

    Isotope dilution is almost exclusively employed with mass spectrometry in applications where high-accuracy is demanded. For example, all National Metrology Institutes rely significantly on isotope dilution when producing certified reference materials. In addition to high-precision analysis, isotope dilution is applied when low recovery of the analyte is encountered. In addition to the use of stable isotopes, radioactive isotopes can be employed in isotope dilution which is often encountered in biomedical appli

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  • Isotope Dilution Mass Spectroscopy - an overview ...

    Measurement of metabolites using stable isotopes is commonly referred to as isotope dilution mass spectrometry (IDMS). The name is derived from the addition of a known amount of an enriched “labeled” form of the same compound that is targeted in a measurement. The ratio of the quantity of unlabeled to labeled compound can be measured, and the concentration then can be determined. For the

  • Isotope Dilution - an overview ScienceDirect Topics

    Isotope dilution thermal ionization mass spectrometry (ID-TIMS) remains the benchmark method for the determination of high-precision U (uranium) and Pb (lead) isotope ratios, due to its sensitivity, ion beam stability, small degree of instrumental mass bias, and low instrumental blank levels (Parrish and Noble, 2003). The geological sciences have seen tremendous growth in the application of in situ methods for

  • Isotope dilution chemistry Britannica

    Isotope dilution, radiochemical method of analysis for measuring the mass and quantity of an element in a substance. The procedure involves adding to a substance a known quantity of a radioisotope of the element to be measured and mixing it with the stable isotope of the element. A sample is then taken from the mixture and analyzed.

  • Isotope dilution - WikiMili, The Best Wikipedia Reader

    2020-09-01  Isotope dilution is almost exclusively employed with mass spectrometry in applications where high-accuracy is demanded. For example, all National Metrology Institutes rely significantly on isotope dilution when producing certified reference materials. In addition to high-precision analysis, isotope dilution is applied when low recovery of the analyte is encountered. In addition to the use of stable isotopes, radioactive isotopes can be employed in isotope dilution

  • Isotope dilution mass spectrometry — A primary method of ...

    2010-11-24  This article describes the application of isotope dilution mass spectrometry (IDMS) to the field of reference material (RM) characterisation focusing on the approach, which is applied by the IDMS group at BAM. Emphasis is placed on IDMS measurements of highest analytical quality. Basic principles as well as the equation system are being recalled.

  • Cited by: 87
  • Isotope-dilution mass spectrometry for exact ...

    Isotopically labeled standards are added in the course of DNA digestion, which allows exact quantification by isotope dilution mass spectrometry. To overcome the major bottleneck of such analyses, we developed a short (~14-min-per-sample) ultra-HPLC (UHPLC) and triple quadrupole mass spectrometric (QQQ-MS) method. Easy calculation of the modification abundance in the genome is

  • Cited by: 11
  • Isotope Dilution Mass Spectrometry and the National ...

    2003-03-05  Isotope dilution mass spectrometry and implementation of a common accuracy base for routine medical laboratory analysis: Practice and prospects. Journal of Mass Spectrometry 1995, 30 (5) , 772-774. https://doi.org/10.1002/jms.1190300520; K. E. Murphy, P. J. Paulsen.

  • Cited by: 27
  • Determination of creatinine in human serum by isotope ...

    A method for the determination of creatinine in human serum by isotope dilution-mass spectrometry is described. The analytical procedure comprises the following steps: Addition of [13C,15N2 )creatinine to the serum sample; ion exchange chromatography on the cation exchange resin AG 50W-X2; formation of the trimethylsilyl derivative; gas liquid chromatography-mass spectrometry (GC-MS); selected ion

  • Cited by: 64
  • Isotope dilution - WikiMili, The Best Wikipedia Reader

    2020-09-01  Isotope dilution is almost exclusively employed with mass spectrometry in applications where high-accuracy is demanded. For example, all National Metrology Institutes rely significantly on isotope dilution when producing certified reference materials. In addition to high-precision analysis, isotope dilution is applied when low recovery of the analyte is encountered. In addition to the use of ...

  • Isotope-dilution mass spectrometry for exact ...

    Isotope-dilution mass spectrometry for exact quantification of noncanonical DNA nucleosides. Traube FR(1), Schiffers S(1), Iwan K(1), Kellner S(1), Spada F(1), Müller M(1), Carell T(2). Author information: (1)Center for Integrated Protein Science Munich (CiPSM), Department of Chemistry, Ludwig-Maximilians-Universität München, Munich, Germany. (2)Center for Integrated Protein Science Munich ...

  • Isotope Dilution Mass Spectrometry and the National ...

    Isotope dilution mass spectrometry and implementation of a common accuracy base for routine medical laboratory analysis: Practice and prospects. Journal of Mass Spectrometry 1995 , 30 (5) ,

  • Determination of creatinine in human serum by isotope ...

    The lower limit of detection of the mass spectrometer in the selected ion monitoring mode is about 0.5 ng creatinine with a signal to noise ratio of 3:1 The accuracy of the method is achieved by the use of the isotope dilution principle in combination with GC-MS. In view of the high specificity and exact control of recovery, the procedure for the measurement of creatinine in human serum, as ...

  • Simultaneous quantification of hemagglutinin and ...

    We present a liquid chromatography-tandem mass spectrometry (LC/MS/MS) method for the absolute quantification of viral proteins in a complex mixture. Through use of an isotope dilution approach, HA and NA from viral subtypes H1N1, H3N2, and B were determined both directly and rapidly. Three peptides of each subtype were used in the analysis of HA to ensure complete digestion of the protein

  • Isotope Dilution Mass Spectrometry (RSC Publishing) Jose ...

    Isotope Dilution Mass Spectrometry (IDMS) has become an essential tool in research laboratories and is increasingly used in routine analysis labs (including environmental, food safety and clinical applications). This is the first textbook to present a comprehensive and instructive view of the theory and applications of this growing technique. The main objective of this book is to cover the ...

  • (PDF) Isotope Dilution Mass Spectrometry - A Primary ...

    Isotope Dilution Mass Spectrometry - A Primary Method of Measurement and Its Role for RM Certification. 147. because the precision was only 0.09 %. The

  • Chapter 3 The measurement technique of isotope dilution ...

    Isotope dilution mass spectrometry is a direct ratio method which has been identified by the Consultative Committee for Amount of Substance (CCQM) of the International Committee for Weights and Measures (CIPM) to have the potential to be a primary method [1]. Isotope dilution measurements can be made with inductively coupled plasma mass spectrometry (ICP-MS), which is specifically

  • Isotope dilution SPME GC/MS for the determination of ...

    2005-11-14  Agnieszka Anna Krata, Marcin Wojciechowski, Ewa Bulska, Reference values of methyl mercury mass fractions in new type of environmental matrix-matching materials for speciation analysis assigned by species-specific isotope dilution inductively coupled plasma mass spectrometry and high-performance liquid chromatography, Microchemical Journal, 10.1016/j.microc.2019.03.067, 147, (674

  • Uranium isotope dilution mass spectrometry using NBL ...

    The isotope dilution mass spectrometry method of analysis is used to determine the elemental uranium contents in a wide variety of uranium bearing materials. The method is based on the mass spectrometric analysis of a mixture prepared by diluting the sample to be analyzed with a spike of distinctly different isotopic composition to that of the sample.

  • (PDF) Isotope Dilution Mass Spectrometry - A Primary ...

    Isotope Dilution Mass Spectrometry - A Primary Method of Measurement and Its Role for RM Certification. 147. because the precision was only 0.09 %. The

  • Isotope Dilution Mass Spectrometry by Alonso, Jose I. G ...

    Buy Isotope Dilution Mass Spectrometry by Alonso, Jose I. G., Moldovan, Mariella, Gonzalez, Pablo R. online on Amazon.ae at best prices. Fast and free shipping free returns cash on delivery available on eligible purchase.

  • Author: Jose I. G. Alonso, Mariella Moldovan, Pablo R. Gonzalez
  • Guideline on Isotope Dilution Mass Spectrometry (Technical ...

    Isotope dilution mass-spectrometry can be applied to the determination of minute amounts of calcium in distilled water, deionized water and snow melts from ice sheets in Greenland and Antarctica. The amount of sample required is 20 g for snow analysis. In a 100-ml teflon beaker, 0.3 x 10/sup -7/ M of /sup 12/Ca spike in 0.06 g of dilute nitric acid is accurately weighed. Snow melt is poured ...

  • Isotope dilution SPME GC/MS for the determination of ...

    2005-11-14  Agnieszka Anna Krata, Marcin Wojciechowski, Ewa Bulska, Reference values of methyl mercury mass fractions in new type of environmental matrix-matching materials for speciation analysis assigned by species-specific isotope dilution inductively coupled plasma mass spectrometry and high-performance liquid chromatography, Microchemical Journal, 10.1016/j.microc.2019.03.067, 147, (674

  • Isotope Dilution Mass Spectrometry Semantic Scholar

    Isotope Dilution Mass Spectrometry. Known as: ID-MS, IDMS, Isotope Dilution Mass Spectrophotometry A mass spectrometry technique used to increase the precision and accuracy of chemical analysis. A known amount of an enriched isotope of the element Expand. National Institutes of Health Create Alert. Papers overview. Semantic Scholar uses AI to extract papers important to this

  • Isotope Dilution Mass Spectrometry - A Primary Method of ...

    Isotope Dilution Mass Spectrometry - A Primary Method of Measurement and Its Role for RM Certification 137 in RM characterisation. The main reasons are lack of multi-element spikes, risk of cross contamination by other spikes and different chemical behaviour of the analytes. In trace matrix separation each step increases the blank and reduces the analyte recovery, so that commonly 2, 3 or ...

  • Characterisation of reference materials by isotope ...

    This article reviews the application of isotope dilution mass spectrometry (IDMS) to the field of reference material (RM) characterisation within the past 15 years, focusing on elemental and elemental species analysis.Emphasis is placed on liquid and solid RMs and IDMS measurements of the highest analytical quality. Basic principles, as well as the equation system, are being revisited.

  • METHOD 6800 ELEMENTAL AND SPECIATED ISOTOPE DILUTION MASS ...

    1.1 This method consists of two approaches: (1) isotope dilution mass spectrometry (IDMS) for the determination of total metals, elements and (2) speciated isotope dilution mass spectrometry (SIDMS) for the determination of elemental and molecular species. This method is applicable to the determination of total metals, metal species and molecular species at µg/g and sub µg/L levels in water ...

  • Thermal Ionization Mass Spectrometry (TIMS)

    2019-10-29  A TIMS is a magnetic sector mass spectrometer that is capable of making very precise measurements of isotope ratios of elements that can be ionized thermally, usually by passing a current through a thin metal ribbon or ribbons under vacuum. The ions created on the ribbon(s) are accelerated across an electrical potential gradient (up to 10 KV) and focused into a beam via a series of slits and ...

  • Good Practice Guide for Isotope Ratio Mass Spectrometry

    Although (gas source) isotope ratio mass spectrometry (IRMS) pre-dates organic MS it is, only now, undergoing a similar expansion in availability and fields of applications. IRMS is now increasingly used in the forensic sciences which make the highest demands on the reliability of analytical results. The contributors to this Guide are all institutional members of the Forensic Isotope Ratio ...

  • Accurate and precise isotope dilution mass spectrometry ...

    The method, based on isotope dilution gas chromatography–mass spectrometry (ID GC-MS), was developed to be used as a Reference Method for determining glucose concentration in capillary or venous whole blood. Blood samples and standards are pipetted manually with “microcap” micropipettes, which makes it possible to collect samples even at the patient’s bedside. Glucose is quantified as ...

  • Isotope Dilution Mass Spectrometry eBook by Jose Alonso ...

    Read "Isotope Dilution Mass Spectrometry" by Jose Alonso available from Rakuten Kobo. Isotope Dilution Mass Spectrometry (IDMS) has become an essential tool in research laboratories and is increasingly used...

  • Isotope Dilution Mass Spectrometry: RSC (Issues in ...

    2013-04-24  Isotope Dilution Mass Spectrometry (IDMS) is increasingly used in research laboratories and has become an essential tool in routine analysis labs (including environmental and clinical applications). This is the first textbook to present a comprehensive and instructive view of the theory and applications of this growing technique. The first part of this textbook offers a uniform theoretical ...

  • Isotope Dilution Mass Spectrometry Semantic Scholar

    Isotope Dilution Mass Spectrometry. Known as: ID-MS, IDMS, Isotope Dilution Mass Spectrophotometry A mass spectrometry technique used to increase the precision and accuracy of chemical analysis. A known amount of an enriched isotope of the element Expand. National Institutes of Health Create Alert. Papers overview. Semantic Scholar uses AI to extract papers important to this

  • Isotope Dilution Mass Spectrometry - A Primary Method of ...

    Isotope Dilution Mass Spectrometry - A Primary Method of Measurement and Its Role for RM Certification 137 in RM characterisation. The main reasons are lack of multi-element spikes, risk of cross contamination by other spikes and different chemical behaviour of the analytes. In trace matrix separation each step increases the blank and reduces the analyte recovery, so that commonly 2, 3 or ...

  • WO2014104749A1 - Combustion pretreatment-isotope dilution ...

    The present invention relates to combustion pretreatment-isotope dilution mass spectrometry as a method for measuring the concentration of an element to be detected contained in a sample to be detected by using isotope dilution mass spectrometry, including a step of pretreating the sample to be detected by combusting the same during isotope dilution mass spectrometry.

  • Isotope dilution mass spectrometry - NASA/ADS

    In the past isotope dilution mass spectrometry (IDMS) has usually been applied using the formation of positive thermal ions of metals. Especially in calibrating other analytical methods and for the certification of standard reference materials this type of IDMS became a routine method. Today, the progress in this field lies in the determination of ultra trace amounts of elements, e.g. of heavy ...

  • Techniques and Methods 5–A10: Determination of Glyphosate ...

    Lower method detection levels and increased specificity were achieved in the modified method, 0-2141-09, by using liquid chromatography/tandem mass spectrometry (LC/MS/MS). The use of isotope dilution for glyphosate and AMPA and pseudo isotope dilution of glufosinate in place of standard addition was evaluated. Stable-isotope labeled AMPA and ...

  • Good Practice Guide for Isotope Ratio Mass Spectrometry

    Although (gas source) isotope ratio mass spectrometry (IRMS) pre-dates organic MS it is, only now, undergoing a similar expansion in availability and fields of applications. IRMS is now increasingly used in the forensic sciences which make the highest demands on the reliability of analytical results. The contributors to this Guide are all institutional members of the Forensic Isotope Ratio ...

  • How a Mass Spectrometer Identifies Isotopes - dummies

    Mass spectrometry provides valuable information about the structure of a molecular compound, including its isotopes. Because mass spectrometry determines the weights of fragments, atoms that naturally have heavy isotopes become important. Isotopes are atoms that have the same number of protons and electrons, but different numbers of neutrons. Isotope effects are most readily observed in

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